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KMID : 0358420150580020157
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Korean Journal of Obstetrics and Gynecology
2015 Volume.58 No. 2 p.157 ~ p.161
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Neutrophil-lymphocyte and platelet-lymphocyte ratios in endometrial hyperplasia
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Cakmak Bulent
Gulucu Selim
Aliyev Nurlan
Ozsoy Zeki
Nacar Mehmet
Koseoglu Dogan
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Abstract
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Objective: The purpose of present study was to evaluate association between neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) and endometrial hyperplasia (EH).
Methods: One hundred and ten women with abnormal uterine bleeding were included into the study. Blood samples were drawn from all patients to obtain complete blood cell counts, neutrophil-leukocyte ratio and platelet-leukocyte ratio before endometrial curettage procedure initiated. The patients were divided into three groups due to their pathological results: group 1, patients with EH without atypia (n=40); group 2, patients with EH with atypia (n=15); and group 3, patients with neither hyperplasia nor cancer as control group (n=55). Blood cell counts, NLRs and PLRs were compared among these groups.
Results: Based on hemoglobin and platelet counts, there was no significant difference among these groups (P>0.05). Leukocyte and neutrophil counts were higher in group 2 (EH with atypia) than group 1 and group 3 (P<0.01). NLR of group 2 was significantly elevated when compared to group 1 and group 3 (P=0.004). PLR was higher in group 1 and group 2 than control group (P=0.024).
Conclusion: Non-specific inflammatory markers such as NLR and PLR were elevated in women with atypical EH. These markers may be used as a predictor of atypical EH in patients with abnormal uterine bleeding.
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KEYWORD
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Atypia, Blood cells, Endometrial hyperplasia, Inflammatory, Markers
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